Journal article
Comparison of total immunoglobulin G antibody responses to different protein fragments of Plasmodium vivax Reticulocyte binding protein 2b
C Bourke, E Takashima, LJ Chan, MH Dietrich, R Mazhari, M White, J Sattabongkot, WH Tham, T Tsuboi, I Mueller, R Longley
Malaria Journal | BMC | Published : 2022
Abstract
Background: Plasmodium vivax is emerging as the dominant and prevalent species causing malaria in near-elimination settings outside of Africa. Hypnozoites, the dormant liver stage parasite of P. vivax, are undetectable to any currently available diagnostic test, yet are a major reservoir for transmission. Advances have been made to harness the naturally acquired immune response to identify recent exposure to P. vivax blood-stage parasites and, therefore, infer the presence of hypnozoites. This in-development diagnostic is currently able to detect infections within the last 9-months with 80% sensitivity and 80% specificity. Further work is required to optimize protein expression and protein c..
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Grants
Awarded by State Government of Victoria
Funding Acknowledgements
We acknowledge funding from the Foundation of Innovative Diagnostics (FIND), the National Health and Medical Research Council (#1092789, #1134989 and #1043345 to IM, #1143187 to W-HT and #1173210 to RL), the National Institute of Allergy and Infectious Diseases (NIH grant 5R01 AI 104822 to JS for the cohort studies), and the Global Health Innovative Technology Fund (https://www.ghitfund.org/) (T2015-142 to IM). W.-H.T. is a Howard Hughes Medical Institute-Wellcome Trust International Research Scholar (208693/Z/17/Z). We also acknowledge support from the National Research Council of Thailand and the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.